beta Catenin antibody

Catalog No. ABIN4949463

This Mouse Monoclonal antibody specifically detects beta Catenin in WB and IF. It exhibits reactivity toward Human, Chicken, Cow and Dog.

Quick Overview for beta Catenin antibody (ABIN4949463)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity: Human, Chicken, Cow, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Catenin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 9F2

Product Details anti-beta Catenin Antibody

Purification: Protein G affinity chromatography

Immunogen: Chicken b-Catenin was used as the immunogen for the b-Catenin antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Titration of the b-Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1-2 μg/mL,WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the b-Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: Beta Catenin

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]

Pathways: Peptide Hormone Metabolism